Journal of Biosciences

, Volume 1, Issue 1, pp 99–107 | Cite as

Removal of radioactive strontium from the rat by feeding stable strontium

  • S. G. Kshirsagar


The effect of administering the stable isotope of strontium (as phos-phate) at different dietary levels to adult rats (fed on a cereal and pulse-based diet containing 0.4% Ca) on the retention of radiostrontium (89Sr) and radiocalcium (45Ca) in the femur and the whole skeleton was studied for a period up to 6 weeks after an intraperitoneal injection of the two radioisotopes. The ability of strontium to remove89Sr under the above dietary conditions was examined. Feeding Sr at 0.5% or 1% levels for 6 weeks had no effect on the skeletal content of89Sr or45Ca while a dietary regimen of 2% Sr (2000 times the normal content), significantly lowered the89Sr and45Ca content by about 30% in the femur but not in the whole skeleton. At this Sr level, the urinary excretion of the isotopes increased with a concomitant decrease in their excretion in the faeces. This study underscores the limitations of dietary Sr to mobilise89Sr from the bones after it is incorporated in the bone mineral.


89Sr removal Sr feeding rat cereal and pulse diet 


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Copyright information

© Indian Academy of Sciences 1979

Authors and Affiliations

  • S. G. Kshirsagar
    • 1
  1. 1.Biology and Agriculture DivisionBhabha Atomic Research CentreBombay

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