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Journal of Biosciences

, Volume 9, Issue 3–4, pp 203–212 | Cite as

Prediction and comparison of the secondary structure of legume lectins

  • M. Joginadha Swamy
  • M. Venkata Krishna Sastry
  • Avadhesha Surolia
Article

Abstract

Secondary structure prediction for the 4 legume lectins: Concanavalin A, soybean agglutinin, favabean lectin and lentil lectin, was done by the method of Chou and Fasman. This prediction shows that these four lectins fall into a structurally distinct class of proteins, containing high amounts of β-sheet and β-turns. There is a notable similarity in the gross structure of these proteins; all four of them contain about 40–50% of β-sheet, 35–45 % β-turn and 0–10% of α-helix. When the secondary structure of corresponding residues in each pair of these lectins was compared, there was a striking similarity in the Concanavalin A-soybean agglutinin and favabean lectin-lentil lectin pairs, and considerably less similarity in the other pairs, suggesting that these legume lectins have probably evolved in a divergent manner from a common ancestor. A comparison of the predicted potential β-turn sites also supports the hypothesis of divergent evolution in this class of lectins.

Keywords

Secondary structure prediction legume lectins divergent evolution β-turns 

Abbreviations used

LcL

Lentil lectin

Con A

Concanavalin A

CD

circular dichroism

SBA

soybean agglutinin

Favin

favabean lectin

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Copyright information

© Indian Academy of Sciences 1985

Authors and Affiliations

  • M. Joginadha Swamy
    • 1
  • M. Venkata Krishna Sastry
    • 1
  • Avadhesha Surolia
    • 1
  1. 1.Molecular Biophysics UnitIndian Institute of ScienceBangaloreIndia

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