Journal of Biosciences

, Volume 4, Issue 1, pp 25–29 | Cite as

Bacitracin A: Structure-activity relationship

  • S. Rambhav


The single imidazole nucleus of L-histidine residue in bacitracin-A seems to be important for the anti-bacterial activity of the molecule, since iodination, carboxymethylation and coupling of diazobenzene sulphonic acid to the histidine residue in the antibiotic caused 90–94% loss of antibacterial activity of the antibiotic. In contrast, the bacitracin sulphone and sulphoxide derivatives are as active as the parent antibiotic.


Bacitracin-A chemical modification iodination carboxymethylation diazotizetion 


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Copyright information

© Indian Academy of Sciences 1982

Authors and Affiliations

  • S. Rambhav
    • 1
  1. 1.Department of BiochemistryOsmania UniversityHyderabad

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