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Blood lactate behavior after glucose load in diabetes mellitus

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Summary

The aim of this study was to evaluate the relationships between blood lactate and plasma glucose, insulin (IRI) and C-peptide (IRCP) during the first hour of an oral glucose load (OGTT, 100 g). Twelve controls, sixteen non-insulin-dependent (NIDDM) and four insulin-dependent (IDDM) diabetic subjects were studied. A significant increase in blood lactate was observed at 15 min in normal subjects, whereas there was a delayed increase at 45 min in NIDDM subjects, in the presence of IRCP increments of 0.31 nmol/l. In order to have a minimum significant lactate increment, the threshold value of peripheral IRCP increment was about 0.30 nmol/l. In IDDM subjects, despite considerable hyperglycemia, blood lactate concentration remained unchanged throughout the test. In normal and NIDDM subjects there was a significant negative correlation between Δ lactate and Δ glucose (r=−0.89, p<0.001) and a significant positive correlation between Δ lactate and Δ IRCP (r=0.78, p<0.001). In conclusion, hyperglycemia itself and the lack of increase in insulin secretion do not affect blood lactate increase during OGTT; blood concentration of this metabolite depends mainly on an early insulin secretion apt to enhance tissue glucose uptake and to inhibit gluconeogenesis.

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Authors and Affiliations

  1. Istituto Scientifico di Medicina Interna Cattedra di Malattie del Ricambio, Università di Genova, Viale Benedetto XV, 6, 16132, Genova, Italy

    Romano Prando, Valeria Cheli, Paolo Buzzo, Plerluigi Melga, Egle Ansaldi & Salvatore Accoto

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  1. Romano Prando
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  2. Valeria Cheli
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  3. Paolo Buzzo
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  4. Plerluigi Melga
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Prando, R., Cheli, V., Buzzo, P. et al. Blood lactate behavior after glucose load in diabetes mellitus. Acta diabet. lat 25, 247–256 (1988). https://doi.org/10.1007/BF02624820

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  • DOI: https://doi.org/10.1007/BF02624820

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