Abstract
Our experience suggests that there exist what may be termed 3 pedigrees of hereditary prostate cancer. Typical of pedigree 1, three brothers were affected by prostate cancer. A characteristic of this pedigree was the existence of some patients with bladder cancer and some with brain tumor. In pedigree 2, the paternal side of the family had been affected by prostate cancer for 3 generations. It was characteristic of this pedigree that the age at diagnosis was lower with each succeeding generation. In pedigree 3, a father and 2 sons were affected with prostate cancer. In 3 families, there were 9 patients with hereditary prostate cancer. The age at diagnosis ranged from 47 to 84 years, with an average age at diagnosis of 68.7 years, which was 5 years younger than the average age at diagnosis in Japan.
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Nakata, S., Sato, J., Suzuki, T. et al. Three pedigrees of hereditary prostate cancer. Int J Clin Oncol 3, 257–260 (1998). https://doi.org/10.1007/BF02489843
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DOI: https://doi.org/10.1007/BF02489843