Abstract
Background
We investigated retrospectively the records and tissue samples of patients with primary ovarian transitional cell carcinoma to determine clinical and pathologic features.
Methods
The records of 3 patients with ovarian transitional cell carcinoma were reviewed using data from several imaging techniques: transvaginal ultrasound, computed tomography, and magnetic resonance imaging. We also determined levels of several tumor marker molecules; and the level of carbohydrate antigen 125 (CA 125), was examined by means of immunohistochemistry.
Results
The tumors of 2 patients were classified as pure trnasitional cell carcinoma; in the remaining patient, as predominantly transitional cell carcinoma. All tumors were bilateral, and 2 of the 3 tumors formed solid masses. Areas of irregular high intensity signals were seen in magnetic resonance images of the solid parts of the tumors. All 3 tumors tested positive for CA 125; histochemical expression was confined to the tumor cell membrane and/or the cytoplasm in all cases. The tumors of all 3 patients tested negative for carcinoembryonic antigen (CEA), and second-look laparotomies did not reveal any residual neoplasms in any of the patients. The patients have been in a disease-free state for 34, 42, and 14 months, respectively.
Conclusion
Our results suggest that transitional cell carcinomas tend to arise bilaterally and to form solid tumors. Magnetic resonance imaging was a useful diagnostic modality in these cases. Transitional cell carcinoma was characterized by the presence of CA 125 and the absence of CEA.
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References
Austin RM, Norris HJ. Malignant Brenner tumor and transitional cell carcinoma of the ovary: a comparison. Int J Gynecol Pathol 1987;6:29–39.
Silva EG, Robey-Cafferty SS, Smith TL, Gershenson DM. Ovarian carcinomas with transitional cell carcinoma pattern. Am J Clin Pathol 1990;93:457–465.
Robey SS, Silva EG, Gershenson DM, McLemore D, El-Naggar A, Ordonez NG. Transitional cell carcinoma in high-grade high-stage ovarian carcinoma. Cancer 1989;63:839–847.
Gershenson DM, Silva EG, Mitchell MF, Atkinson EN, Wharton JT. Transitional cell carcinoma of the ovary: a matched control study of advanced-stage patients treated with cisplatin-based chemotherapy. Am J Obstet Gynecol 1993;168:1178–1187.
Changes in definitions of clinical staging for carcinoma of the cervix and ovary: International Federation of Gynecology and Obstetrics. Am J Obstet Gynecol 1987;263–264.
Mostofi FK. Histological typing of urinary bladder tumors. In: International histological classification of tumors. Geneva: World Health Organization, 1973:17.
Yanagida M, Kanda E, Yamashita S, Tsujimoto S, Hirano T, Oomura T, Miura M. A case of ovarian transitional cell carcinoma. Tr Soc Pathol Jpn 1994;83:338.
Ayhan A, Tuncer ZS, Sarac E, Ayhan A. Transitional cell carcinoma of the ovary. Int J Gynecol Cancer 1996;6:183–185.
Soslow RA, Rouse RV, Hendrickson MR, Silva EG, Longacre TA. Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis. Int J Gynecol Pathol 1996;15:257–265.
Roth LM, Gersell DJ, Ulbright TM. Ovarian Brenner tumors and transitional cell carcinoma: recent developments. Int J Gynecol Pathol 1993;12:128–133.
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Sugiyama, T., Nishida, T., Kataoka, A. et al. Transitional cell carcinoma of the ovary: Report of three cases. Int J Clin Oncol 2, 92–96 (1997). https://doi.org/10.1007/BF02488879
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DOI: https://doi.org/10.1007/BF02488879