Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 1, pp 743–746 | Cite as

An experimental model of pseudotuberculosis infection in monkeys

  • I. V. Marakulin
  • I. V. Darmov
  • I. P. Pogorel'skii
  • V. I. Drobkov
  • V. N. Pautov
Microbiology and Immunology
  • 18 Downloads

Abstract

An experimental model of pseudotuberculosis infection was developed usingPapio hamadryas monkeys. Clinical manifestations and some microbiological and immunological aspects of pseudotuberculosis caused by oral infection of animals are studied. The values of LD50 of the pseudotuberculosis agent are established for monkeys, white mice, and guinea pigs. Oral infection of monkeys with sublethal doses ofYersinia pseudotuberculosis is found to induce a pronounced specific immunity. The efficacy of immunoblotting for serologic diagnosis of pseudotuberculosis in clinically obscure cases is demonstrated.

Key Words

pseudotuberculosis monkeys oral infection immunoblotting 

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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • I. V. Marakulin
    • 1
  • I. V. Darmov
    • 1
  • I. P. Pogorel'skii
    • 1
  • V. I. Drobkov
    • 1
  • V. N. Pautov
    • 1
  1. 1.Research Institute of MicrobiologyMinistry of Defence of RussiaKirov

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