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Pediatric Radiology

, Volume 18, Issue 1, pp 20–23 | Cite as

Change of thymic size during and following cytotoxic therapy in young patients

  • U. Bode
  • W. Scheidt
Originals

Abstract

In a retrospective study, 108 thoracic CT-scans of 18 patients aged 5–25 who had received cytotoxic treatment for solid tumors were evaluated. The thymic size decreased in 15/17 patients during treatment and increased in 14/15 after the end of therapy. In 5/5 patients, the change could also be detected with relapse therapy. These changes have to be considered in the evaluation of a mediastinal mass suspected of metastasis during and following cytotoxic therapy.

Keywords

Public Health Retrospective Study Solid Tumor Young Patient Mediastinal Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Baron RL, Lee JKT, Sagel SS, Peterson RR (1982) Computed tomography of the normal thymus. Radiology 142: 121PubMedGoogle Scholar
  2. 2.
    Baron RL, Lee JKT, Sagel SS, Levitt RG (1982) Computed tomography of the abnormal thymus. Radiology 142: 127PubMedGoogle Scholar
  3. 3.
    Francis IR, Glazer GM, Bookstein FL, Gross BH (1985) The thymus: re-examination of age-related changes in size and shape. AJR 145: 249PubMedGoogle Scholar
  4. 4.
    Heiberg E, Wolverson MK, Sunderam M, Nouri S (1982) Normal thymus: CT. AJR 138: 491PubMedGoogle Scholar
  5. 5.
    Moore AV, Korobkin M, Olanow W, Heaston DK, Ram PC, Dunnick NR, Silverman PM (1983) Age-related changes in the thymus gland: CT-pathological correlation. AJR 141: 241PubMedGoogle Scholar
  6. 6.
    Salonen OLM, Kivisaari ML, Somer JK (1984) Computed tomography of the thymus of children under 10 years. Pediatr Radiol 14: 373CrossRefPubMedGoogle Scholar
  7. 7.
    Siegel MJ, Sagel SS, Reed K (1982) The value of computed tomography in the diagnosis and management of pediatric mediastinal abnormalities. Radiology 142: 149PubMedGoogle Scholar
  8. 8.
    Caffey J, Silbey R (1960) Regrowth and overgrowth of the thymus after atrophy induced by the oral administration of adrenocorticosteroids to human infants. Pediatrics 26: 762PubMedGoogle Scholar
  9. 9.
    Carmosino L, DiBenedetto A, Feffer S (1985) Thymic hyperplasia following successful chemotherapy. Cancer 56: 1526PubMedGoogle Scholar
  10. 10.
    Cohen M, Hill CA, Cangir A, Sullivan MP (1980) Thymic rebound after treatment of childhood tumors. AJR 135: 151PubMedGoogle Scholar
  11. 11.
    Hill CA, Dodd GD (1970) Thymic hyperplasia simulating mediastinal metastasis. Tex Med J 66: 78Google Scholar
  12. 12.
    Shin M, Ho K (1983) Diffuse thymic hyperplasia following chemotherapy for nodular sclerosing Hodgkin's disease. Cancer 51: 30PubMedGoogle Scholar
  13. 13.
    Woodhead PJ (1984) Thymic enlargement following chemotherapy. Br J Radiol 57: 932PubMedCrossRefGoogle Scholar
  14. 14.
    Bartoye A, Bereaud C, Depierre A (1956) Hypertrophie thymique et primoinfection du nourrisson. Pediatrie (Lyon) 11: 545Google Scholar
  15. 15.
    Gelfand DW, Goldman AS, Law EJ (1972) Thymic hyperplasia in children recovering from thermal burns. J Trauma 12: 813PubMedCrossRefGoogle Scholar
  16. 16.
    Risk G, Cuteo L, Amplatz K (1972) Rebound enlargement of the thymus after successful corrective surgery for transposition of the great vessels. AJR 116: 528Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • U. Bode
    • 1
  • W. Scheidt
    • 1
  1. 1.Children's Hospital and Radiological ClinicUniversity of BonnBonnFRG

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