Abstract
A male infant with cloverleaf skull and multiple other birth defects born to unrelated, healthy, young parents is presented. Radiologic findings in addition to the cloverleaf skull configuration included short, wide clavicles, winged scapulae, unusual shapes of ribs with abnormal spacing between them and with prominent costovertebral junctions, and widely separated ischia. Ulnae appeared angular with probable fusion to the midportion of the radial bones bilaterally. There was polydactyly of the hands and feet with grossly abnormal metacarpal and metatarsal bones. Skeletal maturation was normal. Computed tomography of the skull showed dilated lateral and third ventricles as well as agenesis of the corpus callosum. The mother denies any teratogenic exposure during the pregnancy. The findings in this infant do not seem to fit into any previously described syndrome.
Similar content being viewed by others
References
Iannaconne G, Gerlini G (1974) The so-called “cloverleaf skull syndrome”. A report of three cases with a discussion of its relationship with thanatophoric dwarfism and the craniostenosis. Pediatr Radiol 2/3: 175
Katayama KP, Wilkinson EJ, Hermann J, Glaspey JC, Agarwal AB, Roesler MR, Mattigly RF (1980) Clinical deliniation of trisomy 9 syndrome. Obstet Gynecol 56: 665
Holtermueller K, Wiedemann HR (1960) Kleeblattschädel-Syndrom. Med Monatsschr 14: 439
Chervenak FA, Blakemore KJ, Isaacson G, Mayden K, Hobbins JC (1983) Antenatal sonographic findings of thanotophoric dysplasia with cloverleaf skull. Am J Obstet Gynecol 146: 984
Aksu F, Mietens C (1979) Kleeblaatschädel-Syndrom. Klin Paediatr 191: 418
Kozlowski K, Warren PS, Fisher CC (1985) Cloverleaf skull with generalized bone dysplasia. Pediatr Radiol 15: 412
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Say, B., Poznanski, A.K. Cloverleaf skull associated with unusual skeletal anomalies. Pediatr Radiol 17, 93–96 (1987). https://doi.org/10.1007/BF02388081
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02388081