Abstract
Several authors have reported an association between neuroblastoma and congenital heart disease; others contend that, unlike specific wellknown associations between malignancy and congenital defects (Wilm's tumor and aniridia, leukemia and Down's syndrome), no real relationship exists. We present three cases of cyanotic congenital heart disease in which subclinical neuroblastoma was found. We speculate that abnormal neural crest cell migration and development may be a common link between cardiac malformations and congenital neuroblastoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Reisman M, Goldenberg E, Gordon J (1966) Congenital heart disease and neuroblastoma. Am J Dis Child p 308
Beckwith J, Perrin E (1963) In situ neuroblastomas: a contribution to the natural history of neural crest tumors. Am J Pathol 43: 1089
de la Monte S, Hutchins G, Moore G (1985) Peripheral neuroblastic tumors and congenital heart disease: possible role of hypoxic states in tumor induction. Am J Pediatr Hematol Oncol 7: 109
Sy WM, Edmonson JH (1968) The developmental defects associated with neuroblastoma-etiologic implications. Cancer 22: 234
Miller RW, Fraumeni J Jr, Hill J (1968) Neuroblastoma: epidemiologic approach to its origin. Am J Dis Child 115: 253
Berry C, Keeling J, Hilton C (1970) Coincidence of congenital malformation and embryonic tumors of childhood. Arch Dis Child 45: 229
Besson W, Kirby M, Van Mierop L, Teabeaut J II (1986) Effects of the size of lesions of the cardiac neural crest at various embryonic ages on incidence and types of cardiac defects. Circulation 73: 360
Kirby M, Gale T, Steward D (1983) Neural crest cells contribute to aorticopulmonary septum. Science 220: 1059
Gaisie G, Oh KS, Young L (1979) Coexistent neuroblastoma and Hirschsprung's disease-another manifestation of the neurocristopathy? Pediatr Radiol 8: 161
Roshkow J, Haller J, Berdon W, Sare S (1987) Hirschsprung's disease, Ondine's cure and the neurocristopathy syndrome. Presented ARRS meeting
Bolande R (1974) The neurocristopathies: a unifying concept of disease arising in neural crest maldevelopment. Hum Pathol 5: 409
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bellah, R., D'Andrea, A., Darillis, E. et al. The association of congenital neuroblastoma and congenital heart disease. Pediatr Radiol 19, 119–121 (1989). https://doi.org/10.1007/BF02387900
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02387900