Abstract
Thirty uremic patients were classified to 5 subgroups according to histological criteria as osteitis fibrosa (OF), mixed OF plus osteomalacia (OM), mild hyperparathyroidism, aplastic bone disease and OM. Serum level of PTH was elevated in OF while it was lowered in aplastic bone disease. Serum level of PTH and ALP well correlated with bone formation parameters of histomorphometry suggesting that these parameters could predict turnover of bone in uremic patients. Serum level of aluminum was correlated with the duration of hemodialysis and aluminum positive bone surface. This might correspond to the aluminum hydroxide consumption. No double tetracycline uptake was observed in the diabetic patients and their serum PTH level was considerably low, suggesting that lowered PTH might be partly responsible for the low bone turnover status.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Villanueva, A.R.: A bone stain for osteoid seams in fresh unembedded mineralized bone. Stain Technol. 49: 1–8, 1974.
Maloney, N.A., Ott, S.M., Alfrey, A.C., Miller, N. L., Coburn, J.W. and Sherrard, D.J.: Histological quantitation of aluminum in iliac bone from patients with renal failure. J. Lab. Clin. Med. 99: 206–216, 1982.
Coupron, P., Meunier, P.J., Bressot, C and Giroux J.M.: Amount of bone in iliac crest biopsy. Significance of the trabecular bone volume. Its values in normal and in pathological conditions. In: Bone Histomorphometry (P.J. Meunier ed.), Laboratoirede Recherches sur l'Histodynamique Osseuse, Lyon. pp 39–53, 1977.
Parfitt, A.M., Drezner, M.K., Glorieux, F.H., Kanis, J.A., Malluche, H., Meunier, P.J., Ott, S.M. and Recker, R.R.: Bone histomorphometry: Standardization of nomenclature, symbols, and units. J. Bone Miner. Res. 2: 595–610, 1987.
Andress, D.L., Endres, D.B., Maloney, N.A., Kopp, J.B., Coburn, J.W. and Sherrard, D.J.: Comparison of parathyroid hormone assays with bone histomorphometry in renal osteodystrophy. J. Clin. Endocrinol. Metab. 63: 1163–1169, 1986.
Recker, R.R., Kimmel, D.B., Parfitt, A.M., Davies, K.M., Keshawarz, N. and Hinders, S.: Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females. J. Bone Miner. Res. 3: 133–144, 1988.
Ohara, K., Aoyagi, R., Sato, T., Gejyo, F., Arakawa, M., Takahashi, H., Miura, Y.: Bone aluminium accumulation and renal osteodystrophy in hemodialysis patients. Kidney Metab. Bone Dis. 3: 115–120, 1990. (in Japanese)
Heaf, J.G., Podenphant, J. and Andersen, J.R.: Bone aluminum deposition in maintenance dialysis patients treated with aluminium-free dialysate: Role of aluminium hydroxide consumtion. Nephron 42: 210–216, 1986.
Cournot-Witmer, G., Plachot, J., Bourdeau, A., Lieberherr, M., Jorgetti, V., Mendes, V., Halpern, S., Hemmerle, J., Drueke, T. and Balsan S.: Effect of aluminum on bone and cell localization. Kidney Int. 29 (suppl. 18): S 37–40, 1986.
Charhon, S.A., Delmas, P.D., Malaval, L., Chavassieux, P.M., Arlot, M., Chapuy, M. and Meunier, P.J.: Serum bone Gla-protein in renal osteodystrophy: Comparison with bone histomorphometry. J. Clin. Endocrinol. Metab. 63: 892–897
McNair, P., Christensen, M.S., Madsbad, S., Christiansen, C., Transbol, I.: Hypoparathyroidism in diabetes mellitus. Acta Endocrinol. 93: 81–86, 1981.
Witt, M.F., White, N.H., Santiago, J.V., Seino, Y. and Avioli, L.V.: Use of oral calcium loading to characterize the hypercalciuria of young insulindependent diabetics. J. Clin. Endocrinol. Metab. 57: 94–100, 1983.
Andress, D.L., Hercz, G., Kopp, J.B., Endres, D.B., Norris, K.C., Coburn, J.W. and Sherrard, D.J.: Bone histomorphometry of renal osteodystrophy in diabetic patients. J. Bone Miner. Res. 2: 525–531, 1987.
Author information
Authors and Affiliations
About this article
Cite this article
Tanizawa, T., Takahashi, H.E., Ito, A. et al. Bone histomorphometry in chronic renal failure. J Bone Miner Metab 11, S47–S52 (1993). https://doi.org/10.1007/BF02383843
Issue Date:
DOI: https://doi.org/10.1007/BF02383843