Pharmaceutisch Weekblad

, Volume 5, Issue 5, pp 213–216 | Cite as

201Tl-diethyldithiocarbamate: a possible radiopharmaceutical for brain imaging

  • A. Vyth
  • P. J. Fennema
  • J. B. van der Schoot
Original Articles


For estimating regional brain perfusion with a gamma camera lipophilic radiopharmaceuticals are required. This paper describes the development of201Tl-diethyldithiocarbamate (201TlDDC). First the compound NaDDC was tested for stability and an assay was developed. Next the201TlDDC complex was prepared and checked for lipophilicity and stability by paper chromatography. A scintigraphic pilot study using this agent in a rabbit showed considerable brain uptake, compared to201TlCl. Finally we performed a study in rats on the distribution of201TlDDC in different organs. The results confirmed the lipophilicity of the agent. Within the first hour the percentage of injected dose per gram tissue was 2.73% in the cerebrum and 1.35% in the cerebellum. These data are in good agreement with some other agents used for assessment of brain blood flow.


Public Health Blood Flow Internal Medicine Pilot Study Regional Brain 
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  1. 1.
    Oldendorf WH. Clinical applications of brain blood flow studies. Semin Nucl Med 1971;1:107–19.PubMedGoogle Scholar
  2. 2.
    Oldendorf WH, Kitano M. The symmetry of131I-4-iodoantipyrine uptake by brain after intravenous injection. Neurology (Minneapolis) 1965;15:994–9.Google Scholar
  3. 3.
    Rosenthall L, Mathews G, Stratford J. Radioxenon brain scanning with the gamma-ray scintillation camera. Radiology 1968;89:324–30.Google Scholar
  4. 4.
    Fazio F, Fieschi C, Collice M. Tomographic assessment of cerebral perfusion using single-photon emitter81mKr and a rotating gamma camera. J Nucl Med 1980;21:1139–45.PubMedGoogle Scholar
  5. 5.
    Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H. N-isopropyl-123I-p-iodoamphetamine: single pass brain uptake and washout: binding to brain synaptosomes and localization in dog and monkey brain. J Nucl Med 1980;21:947–52.PubMedGoogle Scholar
  6. 6.
    Sargent T, Shulging AT, Mathis C, Budinger TF. A new iodoamphetamine for rapid positron tomographic measurement of brain blood flow with 122I. In: Proceedings of the third World Congress of Nuclear Medicine and Biology. Nuclear Medicine and Biology. August 29-September 2 1982. Paris, France, 646–9.Google Scholar
  7. 7.
    Hill TC. Single photon emission computed tomography to study cerebral function in man. J Nucl Med 1980;21:1197–9.PubMedGoogle Scholar
  8. 8.
    Sunderman FW. Diethyldithiocarbamate therapy of thallotoxicosis. Am J Med Sci 1967;253:209–20.Google Scholar
  9. 9.
    Hsia YE. Hepatolenticular degeneration: the comparative effectiveness of D-penicillamine, potassium sulphide and diethyldithiocarbamate as decoppering agents. J Pediat 1966;68:921–6.PubMedGoogle Scholar
  10. 10.
    Rauws AG, Ten Ham M, Kamerbeek HM. Influence of the antidote dithiocarb on distribution and toxicity of thallium in the rat. Arch Int Pharmacodyn 1969;182:425–7.PubMedGoogle Scholar
  11. 11.
    Sabbioni E, Gregotti C, Edel J, et al. Organ/tissue disposition of thallium in pregnant rats. Arch Toxicol Suppl 1982;5:225–30.PubMedGoogle Scholar
  12. 12.
    Lie R, Thomas RG, Scott JK. The distribution and excretion of204T1 in the rat, with suggested MPC's and bio-assay procedure. Health Phys 1960;2:334–40.PubMedGoogle Scholar
  13. 13.
    Gehring PJ, Hammond PB. The interrelationship between thallium and potassium in animals. J Pharmacol Exp Ther 1967;155:187–201.PubMedGoogle Scholar
  14. 14.
    Winchell HS, Baldwin RM, Lin TH. Development of I-123-labelled amines for brain studies: localization of I-123 iodophenylalkylamines in rat brain. J Nucl Med 1980;21:940–6.PubMedGoogle Scholar
  15. 15.
    Rapin JR, Bardy A, Coornaert S, et al. New ways of obtaining N-isopropyl-p-iodoamphetamine and pharmacokinetic studies in rat. In: Proceedings of the third World Congress of Nuclear Medicine and Biology: Nuclear Medicine and Biology. August 29–September 2. 1982, Paris, France, 3598–3601.Google Scholar

Copyright information

© Bohn, Scheltema & Holkema 1983

Authors and Affiliations

  • A. Vyth
    • 1
  • P. J. Fennema
    • 1
  • J. B. van der Schoot
    • 1
  1. 1.Department of Nuclear MedicineAcademic Hospital of the University of AmsterdamAZ AmsterdamThe Netherlands

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