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The bioavailability of two new preparations of spironolactone tablets

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Abstract

Two new preparations of spironolactone tablets containing 25 and 100 mg of spironolactone have been characterized by their disintegration time, tablet spironolactone content, dissolution profile and bioavailability in comparison with two known spironolactone preparations as reference material. The preparations were found to possess almost identical characteristics, assuring a proper clinical use of the new tablet preparations. For spironolactone, a positive outcome of thein vitro dissolution test coincides with an excellent bioavailability.

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Authors and Affiliations

  1. Pharmachemie BV, Nijverheidsweg 48-50, 2031, CP Haarlem, The Netherlands

    A. J. Nijkerk, J. M. Vermeer, M. Imanse & D. de Vos

  2. Department of Pharmacology, Sylvius Laboratories, Wassenaarseweg 72, 2333, AL Leiden, The Netherlands

    D. de Vos

Authors
  1. A. J. Nijkerk
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  2. J. M. Vermeer
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  3. M. Imanse
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  4. D. de Vos
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Nijkerk, A.J., Vermeer, J.M., Imanse, M. et al. The bioavailability of two new preparations of spironolactone tablets. Pharmaceutisch Weekblad Scientific Edition 5, 210–212 (1983). https://doi.org/10.1007/BF02332945

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  • DOI: https://doi.org/10.1007/BF02332945

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