Abstract
Optically active 2-(4-hydroxyphenylcarbamoyloxymethyl)-1-methyl-1,2,5,6-tetrahydropyridine is obtained on microbiological transformation of 1-methyl-2-(N-phenyl-carbamoyloxymethyl)-1,2,5,6-tetrahydropyridine with a growing culture of the fungus C. verticillata VKPM F-430. Transformation of 2-(2-phenylethyl)pyridine by a methanoxidating culture of Methylococcus occurs either by hydroxylation of the side chain or conversion of the substrate into N-oxide, depending on the process conditions.
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M. V. Lomonosov Moscow State University, Moscow 119899, Russia; Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 649–655, May, 1999.
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Modyanova, L.V., Duduchava, M.R., Piskunkova, N.F. et al. Microbiological transformation of piperidine and pyridine derivatives. Chem Heterocycl Compd 35, 580–586 (1999). https://doi.org/10.1007/BF02324642
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DOI: https://doi.org/10.1007/BF02324642