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Investigations in the imidazole series 97. Synthesis and some transformations of 5-nitro-5-hydroxyalkylamino- and 4-hydroxy-alkylamino-5-nitroimidazoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

A series of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitro-imidazoles were obtained by the reaction of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-chloro(bromo)imidazoles with amino alcohols. Their reactions with thionyl chloride and carboxylic acid halides and their catalytic hydrogenation were studied.

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Authors
  1. P. M. Kochergin
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  2. L. A. Reznichenko
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  3. R. N. Gireva
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  4. E. V. Aleksandrova
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Additional information

For Communication 96, see [1].

Center of the Chemistry of Medicinal Agents, All-Russia Scientific-Research Chemical-Pharmaceutical Institute, Moscow 119815. Novokuznetsk Scientific-Research Chemical-Pharmaceutical Institute, Novokuznets 654034, Russia. Zaporozh'e State Medical University, Zaporozh'e 33074. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10. pp. 1346–1351, October, 1998.

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Kochergin, P.M., Reznichenko, L.A., Gireva, R.N. et al. Investigations in the imidazole series 97. Synthesis and some transformations of 5-nitro-5-hydroxyalkylamino- and 4-hydroxy-alkylamino-5-nitroimidazoles. Chem Heterocycl Compd 34, 1142–1147 (1998). https://doi.org/10.1007/BF02319492

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  • DOI: https://doi.org/10.1007/BF02319492

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