Abstract
This is the first report of the synthesis of 20-isoxazoline steroids containing a 5,7-diene group by 1,3-dipolar cycloaddition of nitrile oxides to Δ22-steroids, leading to 20-isoxazolin-5′-ylsteroids, or of steroidal 22-nitrile oxides to low-molecular-weight dipolarophiles, giving 20-isoxazolin-3′-ylsteroids.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. A. Akhrem, V. A. Khripach, R. P. Litvinovskaya, and A. V. Baranovskii, Zh. Org. Khim.,25, 1901 (1989).
V. A. Khripach, R. P. Litvinovskaya, and A. V. Baranovskii, Zh. Org. Khim.,26, 1274 (1990).
R. Litvinovskaya, R. Drach, and V. Khripach, Mendeleev Commun., No. 6, 215 (1995).
V. A. Khripach, R. P. Litvinovskaya, A. V. Baranovskii, and A. A. Akhrem, Dokl. Akad. Nauk,318, 597 (1991).
V. A. Khripach, R. P. Litvinovskaya, and A. V. Baranovskii, Mendeleev Commun., No. 3, 117 (1992).
R. P. Litvinovskaya, A. V. Baranovskii, and V. A. Khripach, Zh. Org. Khim.,32, 741 (1996).
R. P. Litvinovskaya, S. V. Drach, A. V. Baranovskii, V. A. Strel'tsova, and V. A. Khripach, Vestsi Akad. Navuk Belarus, Ser. Biyal. Navuk, No. 2, 51 (1996).
R. P. Litvinovskaya, N. V. Koval', and V. A. Khripach, Zh. Org. Khim.,33, 1522 (1997).
V. A. Khripach, R. P. Litvinovskaya, and S. V. Drach, Zh. Org. Khim.,29, 717 (1993).
E. J. Parish and D. H. Miles, J. Org. Chem.,38, 1223 (1973).
Additional information
Institute of Bioorganic Chemistry, Academy of Sciences of Belarus, 220141 Minsk, Belarus. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 267–273, February, 1998.
Rights and permissions
About this article
Cite this article
Litvinovskaya, R.P., Koval', N.V. & Khripach, V.A. Synthesis ofd-provitamins containing a side-chain isozazoline ring. Chem Heterocycl Compd 34, 241–247 (1998). https://doi.org/10.1007/BF02315192
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02315192