Abstract
Amides of 2-oxo- or 2-thiocinchoninic acid have been obtained by the reaction of substituted amides of 2-chlorocinchoninic acid with sodium acetate or sodium sulfide. The reaction of 2-thiocinchoninic acid amides with hydrazine hydrate or ethyl cyanoacetate leads to derivatives of 2-hydrazinocinchoninic acid or (4-carbamoyl-2-quinolyl)cyanoacetic ester respectively, which were also obtained from 2-chlorocinchoninic acid amides.
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References
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Additional information
Perm Pharmaceutical Academy, Perm 614600. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 697–700, May, 1997.
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Mikhalev, A.I., Kon'shin, M.E. & Vakhrin, M.I. Synthesis and conversions of 2-substituted cinchoninic acid amides. Chem Heterocycl Compd 33, 605–608 (1997). https://doi.org/10.1007/BF02291947
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DOI: https://doi.org/10.1007/BF02291947