Chemistry of Heterocyclic Compounds

, Volume 33, Issue 5, pp 605–608 | Cite as

Synthesis and conversions of 2-substituted cinchoninic acid amides

  • A. I. Mikhalev
  • M. E. Kon'shin
  • M. I. Vakhrin


Amides of 2-oxo- or 2-thiocinchoninic acid have been obtained by the reaction of substituted amides of 2-chlorocinchoninic acid with sodium acetate or sodium sulfide. The reaction of 2-thiocinchoninic acid amides with hydrazine hydrate or ethyl cyanoacetate leads to derivatives of 2-hydrazinocinchoninic acid or (4-carbamoyl-2-quinolyl)cyanoacetic ester respectively, which were also obtained from 2-chlorocinchoninic acid amides.


Sodium Acetate Ester Ethyl Sulfide 
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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • A. I. Mikhalev
  • M. E. Kon'shin
  • M. I. Vakhrin

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