Chemistry of Heterocyclic Compounds

, Volume 33, Issue 5, pp 577–582 | Cite as

Synthesis of N-methylmorpholinium 6-methyl-4-(2-thienyl)-5-phenylcarbamoyl-3-cyano-1,4-dihydropyridine-2-thiolate and its reaction with various functionally substituted methyl halides

  • V. D. Dyachenko
  • S. G. Krivokolysko
  • V. P. Litvinov


Condensation of the anilide of acetoacetic acid, thiophene aldehyde, cyanothioacetamide and N-methyl-morpholine gave N-methylmorpholinium 6-methyl-4-(2-thienyl)-5-phenylcarbamoyl-3-cyano-1,4-dihydropyridine-2-thiolate which reacted with various halides ZCH2Hal or H2NCOCH(Ph)Cl to give substituted 2-ZCH2-thio or 2-H2NCOCH(Ph)-thio-1,4-dihydropyridines.


Methyl Organic Chemistry Aldehyde Thiophene Halide 
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  1. 1.
    V. V. Kastron, R. O. Vitolinya, and G. Ya. Dubur, Khim-Farm. Zh., No. 6, 14 (1990).Google Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • V. D. Dyachenko
  • S. G. Krivokolysko
  • V. P. Litvinov

There are no affiliations available

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