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Synthesis of substituted 4-acetylamino-4-phenylpiperidines from the corresponding 4-piperidols under Ritter reaction conditions

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of substituted 4-phenyl-4-piperidols with acetonitrile under Ritter reaction conditions leads to formation of mixtures of the corresponding 4-acetylamino-4-phenylpiperidines and 1,2,5,6-tetrahydropyridines, from which we isolated the target amides by fractional crystallization.

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Authors
  1. T. D. Sokolova
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  2. G. V. Cherkaev
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  3. I. P. Boiko
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  4. A. S. Moskovkin
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Additional information

M. V. Lomonosov State Academy of Fine Chemical Technology, Moscow 117571. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 776–780, June, 1997.

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Sokolova, T.D., Cherkaev, G.V., Boiko, I.P. et al. Synthesis of substituted 4-acetylamino-4-phenylpiperidines from the corresponding 4-piperidols under Ritter reaction conditions. Chem Heterocycl Compd 33, 676–679 (1997). https://doi.org/10.1007/BF02291798

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  • DOI: https://doi.org/10.1007/BF02291798

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