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Synthesis of 4-alkyl-6-amino-3,5-dicyano-2(1H)-pyridinethiones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Condensation of aliphatic aldehydes with cyanothioacetamide has given 4-alkyl-6-amino-3,5-dicyano-2(1H)-pyridinethiones, which have also been synthesized by recyclization of 4-alkyl-2,6-diamino-4H-thiopyrans. Substituted 2-alkylthiopyridines and thieno[2,3-b]pyridines have been prepared from the pyridinethiones. 2,6-Diamino-4-isopropyl-3,5-dicyano-4H-thiopyran and 6-amino-4-isobutyl-2-methylthio-3,5-dicyanopyridine have been studied by x-ray crystallography.

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Authors
  1. V. D. Dyachenko
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  2. S. G. Krivokolysko
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  3. V. N. Nesterov
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  4. V. P. Litvinov
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Additional information

T. G. Shevchenko State Teaching Institute, Lugansk 348011. A. N. Nesmeyanov Institute of Organoelemental Compounds, Moscow 117813. N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 117913. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1655–1663, December, 1997.

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Dyachenko, V.D., Krivokolysko, S.G., Nesterov, V.N. et al. Synthesis of 4-alkyl-6-amino-3,5-dicyano-2(1H)-pyridinethiones. Chem Heterocycl Compd 33, 1430–1437 (1997). https://doi.org/10.1007/BF02291644

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  • DOI: https://doi.org/10.1007/BF02291644

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