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Synthesis of pyrido[3′,2′:4,5]thieno[2,3-c]cinnolines — A new heterocyclic system

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Pyrido[3′,2′:4,5]thieno[2,3-c]cinnolines, new heterocyclic compounds, were obtained in three steps: 1) alkylation of 3-cyanopyridine-2(1H)-thiones by o-nitrobenzyl bromide to give 2-(o-nitrobenzyl)thio-3-cyanopyridines, 2) closure of the thiophene ring in these intermediates to give 3-amino-2-(o-nitrophenyl)thieno[2,3-b]pyridines, and 3) closure of the pyridazine ring by condensation of the amino and nitro groups in triethyl phosphite, leading to the final heterocyclic system.

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Authors
  1. V. A. Artemov
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  2. V. L. Ivanov
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  3. A. V. Koshkarov
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  4. A. M. Shestopalov
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  5. V. P. Litvinov
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Additional information

N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 104–109, January, 1998.

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Artemov, V.A., Ivanov, V.L., Koshkarov, A.V. et al. Synthesis of pyrido[3′,2′:4,5]thieno[2,3-c]cinnolines — A new heterocyclic system. Chem Heterocycl Compd 34, 96–101 (1998). https://doi.org/10.1007/BF02290619

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  • DOI: https://doi.org/10.1007/BF02290619

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