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Purines, pyrimidines, and condensed systems based on them. 17. Reactions of 6,8-dimethyl-3-chloropyrimido-[4,5-c]pyridazin-5,7(6H,8H)dione with C-nucleophiles

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Abstract

6,8-Dimethyl-3-chloropyrimido-[4,5-c]pyridazin-5,7(6H,8H)dione reacts with malonodinitrile, cyanoacetic ester, and nitromethane in the presence of bases to give products of nucleophilic substitution of the chlorine atom. The products containing the cyanoacetic ester and nitromethane residues exist exclusively in the chelated methylidene form in CHCl3 and DMSO solutions. Reactions of pyridazinouracil with methylmagnesium chloride and butyllithium gave products of nucleophilic addition at C(4).

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Authors
  1. A. V. Gulevskaya
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  2. V. V. Goryunenko
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  3. A. F. Pozharskii
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Additional information

For Comuunication 16, see [1].

Rostov State University, Rostov-on-Don 344090, Russia Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1113–1118, August, 2000.

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Gulevskaya, A.V., Goryunenko, V.V. & Pozharskii, A.F. Purines, pyrimidines, and condensed systems based on them. 17. Reactions of 6,8-dimethyl-3-chloropyrimido-[4,5-c]pyridazin-5,7(6H,8H)dione with C-nucleophiles. Chem Heterocycl Compd 36, 975–980 (2000). https://doi.org/10.1007/BF02256984

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  • DOI: https://doi.org/10.1007/BF02256984

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