Abstract
A method has been developed for the synthesis of 4-[2-(bromomethyl)phenyl] tetrahydro-2H-4-pyrancarbonitrile and a study was carried out on the reaction of this compound with primary amines, which, depending on the conditions, leads to either 4-[2-(R-aminomethyl)phenyl]tetrahydro-2H-4-pyrancarbonitriles or hydrobromides of 2-R-aryl-2,3,2′,3′,5′,6′-hexahydrospiro[isoquinoline-4(1H),4′-pyran]-3-imines.
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Taras Shevchenko Kiev University, 252017 Kiev, Ukraine; e-mail: vkysil@mail.univ.kiev.ua. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1035–1041, August, 2000.
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Kisel', V.M., Platonov, M.O., Kostyrko, E.O. et al. Synthesis of spiro[isoquinoline-4,4′-pyran]-3-imines. Chem Heterocycl Compd 36, 905–910 (2000). https://doi.org/10.1007/BF02256974
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DOI: https://doi.org/10.1007/BF02256974