Abstract
Starting from 3,5-dimethylisoxazole the carboxylic acids I and V, the amino acids VIII (L-) and IX (D-), and the ureido acids X (L-) and XI (D-) were prepared, which were used for the synthesis of the new cephalosporins XVIIb, XXa-c (L-), and XXIb (D-). Thein vitro antibacterial activity of these semi-synthetic antibiotics was studied. The resorption of XVIIb was investigated in mice.
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Research Group for Antibiotics of the Hungarian Academy of Sciences, H-4010 Debrecen, P.O. Box 70, Hungary. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1524–1535, November, 1998.
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Sztaricskai, F., Batta, G., Dinya, Z. et al. Synthesis of cephalosporins carrying isoxazolyl acetamido and related side chains. Chem Heterocycl Compd 34, 1296–1307 (1998). https://doi.org/10.1007/BF02256810
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DOI: https://doi.org/10.1007/BF02256810