Abstract
7-Silyl- and 7-germylcephalosporanates in the form of a mixture of 7a and 7b stereoisomers were prepared by the interaction of hydrosilanes and a hydrogermane* with sulfones of tert-butyl esters of 7-diazocephalosporanic acid and 7-diazodesacetoxycephalosporanic acid in the presence of rhodium diacetate. Some of the synthesized substances manifest cytotoxic effects in relation to tumor cellsin vitro, and also inhibit the catalytic activity of the enzyme elastase.
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Generic terms for compounds with the general formula HSiX3 or HGeX3-Translator.
Latvian Institute of Organic Chemistry, Riga LV-1006, Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1504–1509, November, 1998.
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Veinberg, G., Vorona, M., Mucel', D. et al. Sulfones of 7-silyl- and 7-germylcephalosporanates. Chem Heterocycl Compd 34, 1276–1281 (1998). https://doi.org/10.1007/BF02256807
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DOI: https://doi.org/10.1007/BF02256807