Abstract
N-Acylphenothiazines (derivatives of furan and phthalylamino acids) were synthesized, and their neurotropic properties were studied. It was established that the derivatives of phthalyl-ψ-aminobutyric acid increase the duration of hexenal narcosis (by 1.7 times) and increase the stimulant activity of phenamine (by 2.1 times). The glycine derivative prolongs the life of animals under the conditions of hypoxia by 77%.
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References
M. D. Mashkovskii, Medicines [in Russian], Meditsina, Moscow (1987), Part 1, p. 39.
E. Lukevics, M. Trušule, and S. Germane, Eighth International Conference on Phenothiazines and Structurally Related Psychotropic Compounds, Jaipur, India (1996), PS-2.
Additional information
Latvian Institute of Organic Synthesis, Riga LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedineii, No. 2. pp. 265–269, February, 1997.
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Lukevics, E., Trushule, M., Germane, I. et al. Synthesis and neurotropic properties of N-acylphenothiazines. Chem Heterocycl Compd 33, 229–233 (1997). https://doi.org/10.1007/BF02256765
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DOI: https://doi.org/10.1007/BF02256765