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Reaction of 5-hydroxy-3,3,5-trimethylisoxazolidine with acrylic acid esters

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of 5-hydroxy-3,3,5-trimethylisoxazolidine with methyl, ethyl, and tert-butyl acrylates, proceeds as Michael addition, and produces previously, unknown 5-hydroxy-3,3,5-trimethylisoxazolidine-2-propionic acid esters. The structures of the obtained products are proved by1H and13C NMR spectroscopy and by their subsequent transformation into 5-hydroxy-3,3,5-trimethylisoxazolidine-2-propionic acid.

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Authors
  1. A. Yu. Ershov
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  2. N. V. Koshmina
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  3. A. V. Dobrodumov
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Additional information

Institute of High-Molecular Compounds, Russian Academy of Sciences, St. Petersburg 199004, Russia; St. Petersburg State University, St. Petersburg 198904, Russia Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 945–947, July, 1999.

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Ershov, A.Y., Koshmina, N.V. & Dobrodumov, A.V. Reaction of 5-hydroxy-3,3,5-trimethylisoxazolidine with acrylic acid esters. Chem Heterocycl Compd 35, 829–831 (1999). https://doi.org/10.1007/BF02252110

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  • DOI: https://doi.org/10.1007/BF02252110

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