Skip to main content
SpringerLink
Log in

Nitrogen oxide generation during reduction of nitrofuran antibacterial drugs

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Proof of the nitrogen oxide generation during the chemical reduction of a series of nitrofuran derivatives is obtained by polarographic detection of the nitroprusside anion. A hypothesis is made about the mechanism of the peroxynitrite anion formation, which is responsible for the biological activity of nitrofurans during the course of their reduction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. H. Becket and A. E. Robinson,J. Pharmacol. Exp. Ther.,98, 153 (1950).

    Google Scholar 

  2. J. J. Gavin and F. F. Ebetino,Arch. Biochem. Biophys.,113, 399 (1966).

    Google Scholar 

  3. K. Hirano, S. Yoshina, K. Okamkura, and J. Suzuka,Bull. Chem. Soc. Jpn.,40, 2229 (1967).

    Google Scholar 

  4. Z. V. Kuropteva and M. K. Pulatova, in:Magnetic Resonance in Biology and Medicine, Abstracts of the Second All-Union Symposium [in Russian], Chernogolovka (1981), p. 11.

  5. V. E. Shubin and Z. V. Kuropteva,Stud. Biophysica,97, No. 2, 157 (1983).

    Google Scholar 

  6. M. Marletta,Trends Biochem. Sci.,14, 488 (1989).

    Google Scholar 

  7. V. G. Granik, S. Yu. Ryabova, and N. B. Grigor'ev,Usp. Khim.,66, No. 8, 792 (1997).

    Google Scholar 

  8. V. I. Levina, D. I. Grigor'ev, and N. B. Grigor'ev,Khim.-Farm. Zh., No. 8, 55 (1995).

    Google Scholar 

  9. Ya. P. Stradyn' and G. O. Reikhman,Izv. Akad. Nauk Latv. SSR, Ser. Khim., No. 2, 180 (1972).

    Google Scholar 

  10. L. N. Koikov, N. V. Alekseeva, N. B. Grigor'ev, V. I. Levina, K. F. Turchin, T. Ya. Filippenko, M. D. Mashkovskii, M. E. Kaminka, V. B. Nikitin, G. N. Engalycheva, M. A. Kalinkina, I. S. Severina, I. K. ryaposova, and V. G. Granik,Khim.-Farm. Zh., No. 5, 26 (1997).

    Google Scholar 

  11. P. Cogolli, T. Testaferri, M. Tiecco, and M. Tingoli,J. Chem. Soc., Chem. Commun., No. 18, 800 (1979).

    Google Scholar 

  12. A. Denicola, H. Rubbo, D. Rodriguez, and R. Radi,Arch. Biochem. Biophys.,304, 279 (1993).

    Google Scholar 

  13. R. Radi, M. Rodriguez, L. Castro, and R. Telleri,Arch. Biochem. Biophys.,308, 89 (1994).

    Google Scholar 

  14. H. Rubbo, A. Denicola, and R. Radi,Arch. Biochem. Biophys.,308, 96 (1994).

    Google Scholar 

  15. F. J. Peterson,J. Biol. Chem.,254, 4009 (1979).

    Google Scholar 

  16. M. Dershwitz and R. F. Novak,J. Biol. Chem.,257, 175 (1982).

    Google Scholar 

Download references

Authors
  1. N. B. Grigor'ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. V. Chechekin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. P. Arzamaztsev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. I. Levina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. G. Granik
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Russian Federation State Scientific Center NIOPIK, Moscow 103787, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 902–906, July, 1999.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grigor'ev, N.B., Chechekin, G.V., Arzamaztsev, A.P. et al. Nitrogen oxide generation during reduction of nitrofuran antibacterial drugs. Chem Heterocycl Compd 35, 788–791 (1999). https://doi.org/10.1007/BF02252100

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02252100

Keywords

Search

Navigation