Abstract
1,2,3,4-Tetrahydro-2,4,5-trimethylpyrrolo[1,2-c]pyrimidine and its 7-formyl derivative when treated with nitric acid are converted to substituted tetrahydropyrrolo-[1,2-c]pyrimidine-7-carboxylic acid. Conversion occurs through opening of the aminal moiety and formylation of the second molecule of tetrahydropyrrolo[1,2-c]pyrimidine by formaldehyde formed to the 7-formyl-substituted derivative.
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References
T. N. Borisova, A. E. Aliev, E. A. Sorokina, A. A. Sinitsyna, and A. V. Varlamov, Khim. Geterotsikl. Soedin., No. 4, 534 (1995).
Ts. E. Agadzhanyan, A. D. Arutyunyan, and G. L. Arutyunyan, Khim. Geterotsikl. Soedin., No. 7, 929 (1992).
Additional information
Russian University of International Friendship, Moscow 117198. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp 219–222, February, 1999.
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Varlamov, A.V., Borisova, T.N., Sorokina, E.A. et al. Reaction of 1,2,3,4-tetrahydro-2,4,5-trimethylpyrrolo[1,2-c]pyrimidine and its 7-formyl-substituted derivative with nitric acid. Chem Heterocycl Compd 35, 195–198 (1999). https://doi.org/10.1007/BF02251708
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DOI: https://doi.org/10.1007/BF02251708