Abstract
We have studied the aminomethylation reaction of alkyl substituted dipyrrolo[1,2-a; 2′,1′-c]pyrazines and their 5,6-dihydro analogs using different aminomethylating agents. Use of alkoxydialkylaminomethanes (aminoacetals) as Mannich reagents leads to the highest yields of the aminomethylated dipyrrolopyrazines. The compounds prepared have been studied by mass spectrometry.
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For Communication 3, see [1].
M. V. Lomonosov State University, Moscow 119899. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 949–957, July, 1998.
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Terenin, V.I., Ruchkina, E.L., Pleshkova, A.P. et al. Dipyrrolo[1,2-a; 2′,1′-c]pyrazines. 4. Aminomethylation of alkyl substituted dipyrrolo[1,2-a; 2′,1′-c]pyrazines and 5,6-dihydrodipyrrolo[1,2-a; 2′,1′-c]pyrazines. Chem Heterocycl Compd 34, 822–829 (1998). https://doi.org/10.1007/BF02251690
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DOI: https://doi.org/10.1007/BF02251690