Chemistry of Heterocyclic Compounds

, Volume 35, Issue 1, pp 93–96 | Cite as

Synthesis of heterocycles on the basis of anion arylatied products of unsaturated-compounds. Part 4. Cyclocondensation of 3-aryl-2-halo(thiocyanate)propionitriles

  • N. D. Obushak
  • V. S. Matiichuk
  • R. L. Martyak
  • N. I. Ganushchak


Products from the anionic arylation of acrylonitrile show ring closure on interaction with S,N-nucleophiles. The reactions of 3-aryl-2-halopropionitriles with thiourea and ammonium N-phenyldithiocarbamate give respectively 2,4-diimino-5-arylmethylthiazolidines and 4-amino-5-arylmethyl-3-phenyl-4-thiazolin-2-thiones. Hydrogen bromide reacts with 3-aryl-2-thiocyanatopropionitriles to give 4-amino-5-arylmethyl-2-bromothiazoles.


Hydrogen Ammonium Bromide Organic Chemistry Thiourea 
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Copyright information

© Kluwer Academic/Plenum 1999

Authors and Affiliations

  • N. D. Obushak
  • V. S. Matiichuk
  • R. L. Martyak
  • N. I. Ganushchak

There are no affiliations available

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