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Chemistry of Heterocyclic Compounds

, Volume 35, Issue 1, pp 78–83 | Cite as

Synthesis of 3-O-aryl esters of (R,S)-9-(2,3-dihydoxypropyl)adenine and its pyrimidine analogs as new potential inhibitors ofS-adenosyl-L-homocysteine hydrolase

  • A. A. Ozerov
  • M. S. Novikov
  • A. K. Brel'
Article

Abstract

With the aim of searching for new antiviral agents of the acyclonucleoside type, 3-O-arly esters of (R,S)-9-(2,3-dihydroxypropyl)adenine adenine and its pyrimidine analogs have been synthesized. Alkylation of adenine and cytosine by aryl glycidyl ethers in the presence of potassium carbonate affords 46–76% yields of the corresponding N9- and N1-substituted derivatives. The interaction of aryl glycidyl ethers with trimethylsilyl derivatives of uracil and thymine also results in 41–57% yields of N1-monosubstituted products with identical acyclic chain structure.

Keywords

Ester Adenine Pyrimidine Alkylation Cytosine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum 1999

Authors and Affiliations

  • A. A. Ozerov
  • M. S. Novikov
  • A. K. Brel'

There are no affiliations available

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