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Nitrogen and sulfur containing heterocycles. 50. Synthesis and reactions of 6-oxopyrimido[4,5-b][1,4]thiazine-7-carboxylic acid derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Reaction of 5-amino-6 mercaptopyrimidines with diethyl bromomalonate gave ethyl 6-oxopyrimido-[4,5-b][1,4]thiazine-7-carboxylates, from which there was synthesized a series of derivatives at the carboxyl group (amides, hydrazides, and, from the latter, urethanes). Desulfurization of the 6-oxopyrimidothiazine-7-carboxylic acid esters gave N-(pyrimidin-5-yl)monoamides of ethyl malonate.

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References

  1. T. S. Safonova and I. E. Mamaeva,Khim. Geterotsikl. Soedin., No. 1, 101 (1999).

    Google Scholar 

  2. T. S. Safonova and M. P. Nemeryuk,Khim. Geterotsikl. Soedin., No. 5, 714 (1966).

    Google Scholar 

  3. A. F. Keremov, M. P. Nemeryuk, O. L. Aparnikova, and T. S. Safonova,Khim. Geterotsikl. Soedin., No 10, 1332 (1977).

    Google Scholar 

  4. T. S. Safonova,Directed Search for Novel Anti-Tumor and Anti-Viral Drugs [in Russian], Zinatne, Riga (1978), p. 51.

    Google Scholar 

  5. V. Carelli, P. Marchini, F. Miche, L. Moracci, and J. Liso,Tetrahedron Lett.,35, 3421 (1967).

    Article  Google Scholar 

  6. P. M. Kochergin and R. M. Titkova,Zh. Org. Khim.,30, 986 (1994).

    Google Scholar 

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Authors
  1. T. S. Safonova
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  2. A. F. Keremov
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Additional information

For communication 49 see [1].

Center for Chemistry of Drugs—All-Russian Research Chemical-Pharmaceutical Institute, Moscow 119021, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 822–828, June, 1999.

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Safonova, T.S., Keremov, A.F. Nitrogen and sulfur containing heterocycles. 50. Synthesis and reactions of 6-oxopyrimido[4,5-b][1,4]thiazine-7-carboxylic acid derivatives. Chem Heterocycl Compd 35, 733–739 (1999). https://doi.org/10.1007/BF02251635

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  • DOI: https://doi.org/10.1007/BF02251635

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