Summary
The α1-antichymotrypsin and apolipoprotein-E polymorphisms were investigated in patients suffering from alzheimer's syndrome and nondemented psychiatric inpatients as controls. The apolipoprotein E allele 4, well known as risk factor, tended to be elevated in the index group. The frequency of the α1-antichymotrypsin allele A was significantly increased in patients with Alzheimer's syndrome: 0.647 vs. 0483 (chi-square test, p<0.05). We conclude that, apart from the apolipoprotein E allele 4, the α1-antichymotrypsin allele A possibly represents a second genetic factor increasing individual's risk for Alzheimer's syndrome.
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References
Abraham CR, Selkoe DJ, Potter H (1988) Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 52: 487–501
Anderson PA (1995) The molecular genetics of cardiovascular disease. Curr Opin Cardiol 10: 33–43
Brousseau T, Legrain S, Berr C, Gourlet V, Vidal O, Amouyel P (1994) Confirmation of the APO-E4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease. Neurology 44: 342–344
Dilling H, Mombour W, Schmidt MH (eds) (1991) Internationale Klassifikation psychischer Störungen: ICD-10, Kapitel V (F). Klinisch-diagnostische Leitlinien. Weltgesundheitsorganisation (WHO). Huber, Bern Göttingen Toronto
van Duijn CM, de Knijff P, Cruts M, Wehnert A, Havekas LM, Hofman A, van Broeckhoven C (1994) Apolipoprotein E4 allele in a population-based study of earlyonset Alzheimer's disease. Nature Genet 7: 74–78
Faber JP, Polle W, Olek K, Baumann U, Carlson J, Lindmark B, Eriksson S (1993) The molecular basis of α1-antichymotrypsin deficiency in a heterozygote with liver and lung disease. J Hepatol 18: 313–321
Fraser PE, Nguyen JT, McLachlan DR, Abraham CR, Kirschner DA (1993) α1-antichymotrypsin binding to Alzheimer Aß peptides is sequence specific and induces fibril disaggregation in vitro. J Neurochem 61: 298–305
Houlden H, Crook R, Duff K, Collinge J, Roques P, Rossor M, Hardy J (1993) Confirmation that the apolipoprotein E4 allele is associated with late onset, familial Alzheimer's disease. Neurodegeneration 2: 283–286
Kamboh MI, Dharambir KS, Ferrell ER, DeKosky ST (1995) APOE*4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nature Genet 10: 486–488
McKhann G, Drachmann D, Folstein M (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 34: 939–944
Ma J, Yee A, Brewer HB Jr, Das S, Potter H (1994) Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature 372: 92–94
Mahley RW (1988) Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240: 622–630
Matsubara E, Hirai S, Amari M, Shoji M, Yamaguchi H, Okamoto K, Ishiguro K, Harigaya Y, Wakabayashi K (1990) Alpha 1-antichymotrypsin as a possible biochemical marker for Alzheimer-type dementia. Ann Neurol 28: 561–567
Randall LL, Hardy SJS (1989) Unity in function in the absence of consequence in sequence: role of leader peptides in export. Science 243: 1156–1159
Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A (1980) Pathologic verification of ischemic score in differentiation of dementias. Ann Neurol 7: 486–488
Rubinsztein DC (1995) Apolipoprotein E: a review of its roles in lipoprotein metabolism, neuronal growth and repair and as a risk factor for Alzheimer's disease. Psych Med 25: 223–229
Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD (1993) Association of apolipoprotein E allele 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467–1472
Simon B, Weinel R, Hohne M, Watz J, Schmidt J, Kortner G, Arnold R (1994) Frequent alterations of the tumor suppressor genes p53 and DLC in human pancreatic carcinoma. Gastroenterology 106: 1645–1651
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late onset familial Alzheimer disease. Proc Natl Acad Sci USA 90: 1977–1981
Wisniewski T, Castano EM, Golabek A, Vogel T, Frangione B (1994) Acceleration of Alzheimer's fibril formation by apolipoprotein Ein vitro. Am J Pathol 145: 1030–1035
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Thome, J., Baumer, A., Kornhuber, J. et al. Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndrome. J Neural Transm Gen Sect 10, 207–212 (1995). https://doi.org/10.1007/BF02251232
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DOI: https://doi.org/10.1007/BF02251232