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Chronic leg ulcerations resembling vasculitis in two siblings with prolidase deficiency

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Summary

Two cases of prolidase deficiency in two siblings are presented. The patients complained of the typical clinical symptoms of the disease, including chronic leg ulcerations resembling vasculitis. They were mentally retarded, had typical facial characteristics, splenomegaly, and haematologic anomalies. Biochemical and morphological investigations confirmed the diagnosis. In these cases, alterations of the peripheral nervous system and decreased IgA levels were demonstrated for the first time.

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Authors and Affiliations

  1. Metabolic and Medical Genetics Division, Regional Pediatric Hospital “Giovanni XXIII”, Bari, Italy

    F. Papadia & S. Simonetti

  2. Department of Rheumatology, University of Bari, Piazza G. Cesare, 11, 70124, Bari, Italy

    F. P. Cantatore M.D.Ph.D., G. Giannico & M. Carrozzo

Authors
  1. F. P. Cantatore M.D.Ph.D.
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  2. F. Papadia
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  3. G. Giannico
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  4. S. Simonetti
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  5. M. Carrozzo
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Cantatore, F.P., Papadia, F., Giannico, G. et al. Chronic leg ulcerations resembling vasculitis in two siblings with prolidase deficiency. Clin Rheumatol 12, 410–414 (1993). https://doi.org/10.1007/BF02231590

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  • DOI: https://doi.org/10.1007/BF02231590

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