Abstract
Objective
To study the optimum time for ovum pickup after human chorionic gonadotropin (hCG) injection in in vitro fertilization.
Design
Prospective randomized study.
Setting
The Egyptian IVF-ET center.
Patients
Ninety couples with male factor infertility enrolled for intracytoplasmic sperm injection, divided into three groups. Ovum pickup was performed at 35 hr (group A), 36 hr (group B), and 37 hr (group C) after hCG injection.
Results
Number of metaphase II oocytes was significantly higher in group B compared to group A. There was no significant difference between group B and C. Fertilization rate was equal in all groups. The number of fertilized oocytes was significantly higher in group B as compared to group A, and there was no significant difference between groups B and C.
Conclusion
Oocyte maturity in gonadotropin releasing hormone analogue agonist/human menopausal gonadotropin stimulated cycles is attained 36 hr after hCG injection. Oocyte retrieval should not be performed before 36 hr, and there is no risk of spontaneous ovulation between 36 and 37 hr.
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Mansour, R.T., Aboulghar, M.A. & Serour, G.I. Study of the optimum time for human chorionic gonadotropin—Ovum pickup interval in in vitro fertilization. J Assist Reprod Genet 11, 478–481 (1994). https://doi.org/10.1007/BF02215712
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DOI: https://doi.org/10.1007/BF02215712