Abstract
Objective
Our objective was to evaluate retrospectively the influence of different types of anesthesia on the outcome of ovum retrieval.
Methods
Sedation combined with local anesthesia was used on 120 occasions (Group I), epidural block in 139 ovum retrievals (Group II), and general anesthesia in 173 cycles (Group III).
Results
No differences were found in embryo yield or number or the quality of the embryos transferred. Of 99 pregnancies achieved, 66 live deliveries were recorded. Significantly lower clinical pregnancy rates were found in Group III (14.5%) compared with Group II (23.7%; P= 0.018) or Group I (25.8%; P=0.0074). Highly significant differences were found in the delivery rates between Group HI (8.7%), Group II (20.11%; P=0.0017), and Group I (19.2%; P=0.0043).
Conclusion
The use of general anesthesia, especially nitrous oxide, for oocyte retrieval has an adverse effect on IVF outcome. This deleterious effect manifests itself only after embryo transfer and leads to lower pregnancy and delivery rates.
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References
Boyers SP, Lavy G, Russell JB, DeCherney AH: A paired analysis of in vitro fertilization and cleavage rates of first-versus last-recovered preovulatory human oocytes exposed to varying levels of 100% CO2 pneumoperitoneum and general anesthesia. Fertil Steril 1987;48:969–974
Hayes MF, Sacco AG, Savoy-Moore RT, Magyar DM, Endler GC, Moghissi KS: Effect of general anesthesia on fertilization and cleavage of human oocytes in vitro. Fertil Steril 1987;48:975–981
Rosen MA, Roizen MF, Eger EI II, Glass RH, Martin M, Dandekar PV, Dailey PA, Litt L: The effect of nitrous oxide on in vitro fertilization success rate. Anesthesiology 1987;67:42–44
Ben-Nun I, Ghetler Y, Jaffe R, Seigal A, Kaneti H, Fejgin M: Effect of preovulatory progesterone administration on the endometrial maturation and implantation rate after in vitro fertilization and embryo transfer. Fertil Steril 1990;53:276–281
Staessen C, Camus M, Khan I, Smitz J, Van Waesberghe L, Wisanto A, Devroey P, Van Steirteghem AC: An 18-month survey of infertility treatment by in vitro fertilization, gamete and zygote intrafallopian transfer, and replacement of frozen-thawed embryos. J Vitro Fert Embryo Transfer 1989;6(1):22–29
Endler GC, Stout M, Magyar DM, Hayes MF, Moghissi KS, Sacco AG: Follicular fluid concentrations of thiopental and thiamylal during laparoscopy for oocyte retrieval. Fertil Steril 1987;48:828–833
Palot M, Harika G, Pigeon F, Lamiable D, Rendoing J: Propofol in general anesthesia for IVF (by vaginal and transurethral route) follicular fluid concentration and cleavage rate. Anesthesiology 1988;69:A573
Chetkowski RJ, Nass TE: Isofluorane inhibits early mouse embryo development in vitro. Fertil Steril 1988;49(1):171–173
Hinkley RE Jr, Wright BD: Comparative effects of halothane, enflurane, and methoxyflurane on the incidence of abnormal development using sea urchin gametes as an in vitro model system. Anesth Analg 1985;64(10):1005–1009
Coate WB, Kapp RW Jr, Lewis TR: Chronic exposure to low concentrations of halothane-nitrous oxide: Reproductive and cytogenetic effects in the rat. Anesthesiology 1979;50:310–318
Mazze RI, Fujinaga M, Rice SA, Harris SB, Baden JM: Reproductive and teratogenic effects of nitrous oxide, halothane, isoflurane, and enflurane in Sprague-Dawley rats. Anesthesiology 1986;64:339–344
Matt DW, Steingold KA, Dastvan CM, James CA, Dunwiddie W: Effects of sera from patients given various anesthetics on preimplantation mouse embryo development in vitro. J Vitro Fert Embryo Transfer 1991;8(4):191–197
Koblin DD, Watson JE, Deady JE, Stokstad ELR, Eger EI II: Inactivation of methionine synthetase by nitrous oxide in mice. Anesthesiology 1981;54:318–324
Mazze RI, Fujinaga M, Baden JM: Reproductive and teratogenic effects of nitrous oxide, fentanyl and their combination in Sprague-Dawley rats. Br J Anaesth 1987;59(10):1291–1297
Mazze RI: Fertility, reproduction and postnatal survival in mice chronically exposed to isoflurane. Anesthesiology 1985;63(6):663–667
Cohen EN, Bellville JW, Brown BW: Anesthesia, pregnancy, and miscarriage: A study of operating room nurses and anesthetists. Anesthesiology 1971;35:343–347
Knill-Jones RP, Moir DD, Rodrigues LV, Spence AA: Anaesthetic practice and pregnancy: Controlled survey of women anaesthetists in the United Kingdom. Lancet 1972;1:1326
Report of an Ad Hoc Committee on the Effect of Trace Anesthetics on the Health of Operating Room Personnel (American Society of Anesthesiologists): Occupational disease among operating room personnel: a national study. Anesthesiology 1974;41:321–340
Pharoah POD, Alberman E, Doyle P: Outcome of pregnancy among women in anesthetic practice. Lancet 1977;1:34–36
Spence AA, Cohen EN, Brown BW, Knill-Jones RP, Himmelberger DU: Occupational hazards for operating roombased physicians. JAMA 1977;238:955–959
Buring JE, Hennekens CH, Mayrent SL, Rosner B, Greenberg ER, Colton T: Health experiences of operating room personnel. Anesthesiology 1985;62:325–330
Vessey MP: Epidemiological studies of the occupational hazards of anaesthesia: A review. Anaesthesia 1978;33:430–438
Ferstandig LL: Trace concentrations of anesthestic gases: A critical review of their disease potential. Anesth Analg 1978;57:328–345
Rowland AS, Baird DD, Weinberg CR, Shore DL, Shy CM, Wilcox AJ: Reduced fertility among women employed as dental assistants exposed to high levels of nitrous oxide. N Engl J Med 1992;372:993–997
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Gonen, O., Shulman, A., Ghetler, Y. et al. The impact of different types of anesthesia on in vitro fertilization-embryo transfer treatment outcome. J Assist Reprod Genet 12, 678–682 (1995). https://doi.org/10.1007/BF02212892
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DOI: https://doi.org/10.1007/BF02212892