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Pituitary down-regulation in IVF cycles: Is it necessary to use strict criteria?

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Abstract

Purpose

In a retrospective study we have reviewed the data of 570 consecutive IVF cycles in which a GnRH agonist (GnRHa) was started in the early follicular phase (long protocol). Cycles were divided in groups according to estradiol levels before HMG administration: A, <20 pg/ml; B, 20 to 50pg/ml; C, 51 to 100pg/ml. Our objective was to determine if the degree of pituitary suppression had any effect on the ovarian response to stimulation by exogenous gonadotropins, and/or on the IVF outcome.

Results

There were no significant differences in cycle cancellation rates, no. of days of stimulation and ampoules of HMG, serum estradiol after HMG, no. of oocytes retrieved and fertilization rates between groups. Pregnancy rates (19.4%, 21% and 31.8%/cycle, and 24.1%, 27.5% and 37.8%/embryo transfer, respectively) and live-birth rates.(16.2%, 16.1% and 25.0%/cycle, 20.1%, 21.2% and 29.7%/embryo transfer, respectively) were also not significantly different.

Conclusions

The degree of pituitary suppression had no effects on either the ovarian response to gonadotropins (including HMG requirements) or the overall IVF results.

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Authors and Affiliations

  1. Human Reproduction Unit, Department of Obstetrics and Gynecology, Santa Maria's Hospital, Av. Prof. Egas Moniz, 1699, Lisboa Codex, Portugal

    C. Calhaz-Jorge, Fernanda Leal, Isabel Cordeiro, Madalena Barata & A. M. Pereira-Coelho

  2. Department of Clinical Pathology, Santa Maria's Hospital, Lisbon, Portugal

    Helena Proença

Authors
  1. C. Calhaz-Jorge
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  2. Fernanda Leal
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  3. Isabel Cordeiro
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  4. Helena Proença
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  5. Madalena Barata
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  6. A. M. Pereira-Coelho
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Calhaz-Jorge, C., Leal, F., Cordeiro, I. et al. Pituitary down-regulation in IVF cycles: Is it necessary to use strict criteria?. J Assist Reprod Genet 12, 615–619 (1995). https://doi.org/10.1007/BF02212585

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  • DOI: https://doi.org/10.1007/BF02212585

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