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Inhibition of bacterial growthin Vitro by human ejaculate seminal plasma fraction 1 and its possible practical use in male infertility phenomenon

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Abstract

Purpose

Thein vitro bacteriostatic effect on bacteria by a fraction of human ejaculate (HuSePl-Fr1) was studied.

Method

As bacterial indicators,Pseudomonas aeruginosa (Pa), total coliforms (Tc), fecal coliforms (Fc),Escherichia coli (Ec), andStaphylococcus aureus (Sa) were used. These bacterial strains are known as agents that cause urinary and sexually transmitted infections (STI).

Results

Preliminary results suggest that HuSePl-Fr1 has a significantin vitro bacteriostatic effect on Pa and Sa at 42°C. In addition, Pa was inhibited at 37°C after 48 hr incubation. The remaining bacterial indicators were not affected.

Conclusion

The results indicate a possible protective role of HuSePl-Fr1 in treatment of infertile men due to genital infections.

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Authors and Affiliations

  1. Edith Wolfson Medical Center, Blood Bank, 58100, Holon

    Zvi H. Marcus

  2. Department of Chemical Pathology, Tel Aviv University, Medical School, Ramat Aviv, Tel Aviv, Israel

    Laurence M. Lewin

  3. Department of Epidemiological Microbiology, Dr E. Felix Public Health Laboratory and Dr Rappaport Regional Public Health Laboratory, P.O. Box 8355, 61082, Tel Aviv, Israel

    Raul Ginsberg

Authors
  1. Zvi H. Marcus
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  2. Laurence M. Lewin
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  3. Raul Ginsberg
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Marcus, Z.H., Lewin, L.M. & Ginsberg, R. Inhibition of bacterial growthin Vitro by human ejaculate seminal plasma fraction 1 and its possible practical use in male infertility phenomenon. J Assist Reprod Genet 12, 443–446 (1995). https://doi.org/10.1007/BF02211145

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  • DOI: https://doi.org/10.1007/BF02211145

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