Abstract
Analysis of 330 exostoses in 18 patients affected by hereditary multiple exostoses disease suggested a new classification of exostoses as eccentric or full-thickness. Radiographically arrest of metaphyseal remodeling with failure of coning and persistence of the primary metaphyseal trabeculae was evident in full-thickness exostoses. Similar bone lesions can be obtained experimentally with inhibitors of bone turn-over. A localized, peripheral defect in remodeling over a limited time can give a satisfactory explanation also for the origin of eccentric exostoses. The thesis that this is the basic mechanism of exostosis formation is presented.
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Pazzaglia, U.E., Pedrotti, L., Beluffi, G. et al. Radiographic findings in hereditary multiple exostoses and a new theory of the pathogenesis of exostoses. Pediatr Radiol 20, 594–597 (1990). https://doi.org/10.1007/BF02129063
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DOI: https://doi.org/10.1007/BF02129063