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Stability of cisplatin in sodium chloride 0.9% intravenous solution related to the container's material

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Abstract

The stability of cisplatin in sodium chloride 0.9% intravenous solutions contained in glass bottles, polyvinyl chloride bags, polyethylene and polypropylene containers was studied over two weeks. The solubility of cisplatin at 4°C was also studied for possible precipitation. The type of container had no effect on cisplatin decomposition. No precipitation at 4°C was observed within the time period studied.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmacy, Avgd. Diagonal s/n, 08028, Barcelona, Spain

    Montserrat Pujol Cubells, Josefina Prat Aixela & Victòria Girona Brumos

  2. Pharmacy Department, Hospital general de la Vall d'Hebron, 08035, Barcelona, Spain

    Salvador Duran Pou & Miquel Villaronga Flaque

Authors
  1. Montserrat Pujol Cubells
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  2. Josefina Prat Aixela
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  3. Victòria Girona Brumos
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  4. Salvador Duran Pou
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  5. Miquel Villaronga Flaque
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Cubells, M.P., Aixela, J.P., Brumos, V.G. et al. Stability of cisplatin in sodium chloride 0.9% intravenous solution related to the container's material. Pharm World Sci 15 (Suppl 1), 34–36 (1993). https://doi.org/10.1007/BF02116167

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