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Analysis of creams

II. Quantitative determination of drugs in creams by titration in non-aqueous solvents

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Abstract

The possibilities for the determination of active components in creams by acid-base titrations in non-aqueous solvents were investigated. Interference by cream-base components with the titration of weak organic bases and their halides with perchloric acid in acetic acid, and with the titration of weak acids with tetrabutylammonium hydroxide in N,N-dimethylformamide were studied. It appeared to be possible to determine alkaloid halides, salicylic acid, hexachlorophene and methyl salicylate without previous clean-up of the cream samples.

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References

  • British Pharmacopoeia (1980).

  • United States Pharmacopoeia XX (1980).

  • Vaart, F.J. van de, A. Hulshoff andA.W.M. Indemans (1980a)Pharm. Weekbl. 115, 1429–1438;Ibidem (1980b)Pharm. Weekbl. Sci. Ed. 2, 179–185.

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Authors and Affiliations

  1. Laboratory of the Dutch Pharmacists, Alexanderstraat 11, 2514, JL The Hague, The Netherlands

    F. J. Van De Vaart & A. W. M. Indemans

  2. Pharmaceutical Laboratory, Department of Analytical Pharmacy, University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands

    A. Hulshoff & A. W. M. Indemans

Authors
  1. F. J. Van De Vaart
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  2. A. Hulshoff
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  3. A. W. M. Indemans
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Van De Vaart, F.J., Hulshoff, A. & Indemans, A.W.M. Analysis of creams. Pharmaceutisch Weekblad Scientific Edition 4, 16–20 (1982). https://doi.org/10.1007/BF02112352

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  • DOI: https://doi.org/10.1007/BF02112352

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