Skip to main content
SpringerLink
Log in

The influence of the crystallization on the properties of a hydrophobic drug

  • Original Articles
  • Published:
Pharmaceutisch Weekblad Aims and scope Submit manuscript

Abstract

Different phenacetin powders are prepared by recrystallization in water or in aqueous polysorbate 80 solutions. The powders have been characterized by using X-ray diffraction, light microscopy and transmission electron microscopy.

The particle size, surface area and solubilities have been determined. The surface properties of the powders were investigated by measuring the liquid uptake and the amount of polysorbate 80 adsorbed at the crystal surface. The influence of the recrystallization method on the dissolution rate of the powder was studied.

The release of recrystallized phenacetin powders filled into hard gelatin capsules was determined by means of a modified beaker method. An improvement of the hydrophilic properties of the powder enhances the availability of the drug.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Baumann, H. (1967)Fachzeitschrift für das Laboratorium, 540–542.

  • Chiou, W.L., Shaw Jen Chen andN. Athanikar (1976)J. Pharm. Sci. 65, 1702–1703.

    PubMed  Google Scholar 

  • Goodhart, F.W., R.H. MacCoy andF.C. Ninger (1973)J. Pharm. Sci 62, 304–310.

    PubMed  Google Scholar 

  • Greff, R.A., E.A. Setzkorn andW.D. Leslie (1965)J. Am. Oil Chemists Soc. 42, 180–185.

    Google Scholar 

  • Haleblian, J.K. (1975)J. Pharm. Sci. 64, 1269–1288.

    PubMed  Google Scholar 

  • Khan, K.A., andC.T. Rhodes (1972)Pharm. Acta Helv. 47, 594–607.

    PubMed  Google Scholar 

  • Lerk, C.F. (1977)16e Colloquium over Industriële Farmacie, Gent, 66.

  • Ludwig, A. (1979) Ph.D. thesis, Antwerpen.

  • Ludwig, A., W. Jacob andM. van Ooteghem (1978)J. Pharm. Belg. 33, 292–296.

    PubMed  Google Scholar 

  • Newton, J.M., andG.J. Rowley (1970)J. Pharm. Pharmacol. 22, 163S-168S.

    Google Scholar 

  • Newton, J.M., andF.N. Razzo (1977)J. Pharm. Pharmacol. 29, 205–208.

    PubMed  Google Scholar 

  • Zeiss (1977)Informationsblad Mikro 12.

Download references

Author information

Authors and Affiliations

  1. Laboratorium voor Galenische Farmacie, Departement Farmaceutische Wetenschappen, Universitaire Instelling Antwerpen, Universiteitsplein 1, B-2610, Wilrijk, Belgium

    A. Ludwig & M. Van Ooteghem

Authors
  1. A. Ludwig
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Van Ooteghem
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ludwig, A., Van Ooteghem, M. The influence of the crystallization on the properties of a hydrophobic drug. Pharmaceutisch Weekblad Scientific Edition 4, 5–11 (1982). https://doi.org/10.1007/BF02112350

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02112350

Keywords

Search

Navigation