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Determination of ethinyloestradiol in the presence of norethisterone by derivative-difference spectrophotometry

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Abstract

A simple and direct method for the determination of ethinyloestradiol as a minor component in the presence of norethisterone and in oral contraceptive tablets is presented. The method is based on measuring the signal intensity, dδA/dλ and d2δA/dλ 2, of the generated first and second derivative spectra of the δ-absorbance curves obtained by measuring solutions in methanol and methanol-sodium hydroxide at certain wavelengths. The method has been applied to the determination of ethinyloestradiol in oral contraceptive tablets, with a coefficient of variation of less than 2%.

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Authors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, Alexandria University, Alexandria, Egypt

    M. A. Korany, F. A. El-Yazbi, Omyama Abdel-Razak & M. A. Elsayed

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  1. M. A. Korany
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  2. F. A. El-Yazbi
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  3. Omyama Abdel-Razak
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  4. M. A. Elsayed
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Korany, M.A., El-Yazbi, F.A., Abdel-Razak, O. et al. Determination of ethinyloestradiol in the presence of norethisterone by derivative-difference spectrophotometry. Pharmaceutisch Weekblad Scientific Edition 7, 163–166 (1985). https://doi.org/10.1007/BF02097254

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  • DOI: https://doi.org/10.1007/BF02097254

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