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Anthracycline antitumour agents

A review of physicochemical, analytical and stability properties

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Abstract

A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furthermore, the stability of anthracyclines in solutions, in pharmaceutical preparations and in biological media is discussed.

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  1. Department of Analytical Pharmacy, Subfaculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511, GH Utrecht, The Netherlands

    J. Bouma, J. H. Beijnen, A. Bult & W. J. M. Underberg

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Bouma, J., Beijnen, J.H., Bult, A. et al. Anthracycline antitumour agents. Pharmaceutisch Weekblad Scientific Edition 8, 109–133 (1986). https://doi.org/10.1007/BF02086146

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