Abstract
The efficacy of oral ciprofloxacin to prevent bacterial infections during the first three months after allogeneic bone marrow transplantation (BMT) was assessed prospectively. Twenty-three recipients of lymphocyte depleted marrow grafts received ciprofloxacin orally, 500 mg twice daily for 90 days after BMT. Nine patients had no infections during ciprofloxacin prophylaxis; in the remaining 14 patients 19 febrile episodes occurred. No infections could be attributed to Gram-negative rods nor to fungal micro-organisms on the basis of the micro-organisms isolated. One infection, a pneumonia due toBacteroides melaninogenicus, proved to be fatal. Allergic skin reactions were observed in three patients, but neither hematological nor nephrological side-effects could be substantiated in patients who were treated concomitantly with cyclosporine. Prolonged administration of ciprofloxacin turned out to be safe and effective in preventing serious aerobic bacterial infections during the first three months after BMT.
Similar content being viewed by others
References
Winston DJ, Ho G, Champlin RE, and Gale RP. Infectious complications of bone marrow transplantation. Exp Hematol 1984;12:205–15.
Van der Waay D. Colonization resistance of the digestive tract: clinical consequences and implications. J Antimicrob Chemother 1982;10:263–70.
Thompson JF, Chalmers DHK, Hunnisett AGW, Wood RFM, Morris PJ. Nephrotoxicity of trimethoprim and cotrimoxazole in renal allograft recipients treated with cyclosporin. Transplantation 1983;36:204–7.
Brumfitt W, Franklin I, Grady D, Hamilton-Miller JMT, and Iliffe A. Changes in the pharmacokinetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers. Antimicrob Agents Chemother 1984;26:757–61.
Muytjens HL, Van der Ros-van de Repe J, Van Veldhuizen G. Comparative activities of ciprofloxacin (Bay o 9867), norfloxacin, pipemidic acid, and naladixic acid. Antimicrob Agents Chemother 1983;24:302–4.
De Witte T, Raymakers R, Plas A, Koekman E, Wessels J, and Haanen C. Bone marrow repopulation capacity after allegeneic bone marrow transplantation of lymphocyte depleted bone marrow using counterflow centrifugation. Transplantation 1984;37:151–5.
Cohen J, Donelly JP, Worsley AM, et al. Septicemia caused by viridans streptococci in neutropenic patients with leukemia. Lancet 1983;II:1452–4.
Winston DJ, Ho WG, Nakao SL, Gale RP, and Champlin RE. Norfloxacin versus Vancomycin/Polymyxin for prevention of infections in granulocytopenic patients. Am J Med 1986;80:884–90.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
de Witte, T., Novakova, I., Branolte, J. et al. Long-term oral ciprofloxacin for infection prophylaxis in allogeneic bone marrow transplantation. Pharmaceutisch Weekblad Scientific Edition 9 (Suppl 1), S48–S52 (1987). https://doi.org/10.1007/BF02075260
Issue Date:
DOI: https://doi.org/10.1007/BF02075260