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Pediatric Radiology

, Volume 20, Issue 6, pp 440–443 | Cite as

The effect of Hexabrix tracheobronchography on the ultrastructure of the airway epithelium

  • V. Konrádová
  • S. T⫲ma
  • J. Kanta
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Abstract

The ultrastructure of the airway epithelium was studied after experimental Hexabrix tracheobronchography. Serious damage to the tracheal epithelium due to Hexabrix was recorded. 81±5% of goblet cells were stimulated to discharge mucus. 43±3% were completely exhausted and degenerated. The ciliated cells displayed vacuolar degeneration or severe pathological alteration. The average number of cilia/μm2 fell to 3.3±0.5. As morphological signs of impaired selfcleaning ability the inspissated mucus and numerous bacteria appeared in the area of the disorganized ciliary border.

Keywords

Public Health Goblet Cell Airway Epithelium Ciliated Cell Pathological Alteration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Althoff J, Richter-Reichhelm HB, Green U, Kracke D (1981) Scanning electron microscopical investigation on the respiratory epithelium of the syrian golden hamster III. Zbl Bakt Hyg I Abt Orig B 174: 249Google Scholar
  2. 2.
    Gordon RE, Lane BP (1976) Regeneration of rat tracheal epithelium after mechanical injury. Am Rev Resp Dis 113: 799PubMedGoogle Scholar
  3. 3.
    Hulbert WC, Forster BB, Laird W (1982) An improved method for fixation of the respiratory epithelial surface with the mucous and surfactant layers. Lab Invest 47: 354PubMedGoogle Scholar
  4. 4.
    Keenan KP, Combs JW, McDowell EM (1982) Regeneration of hamster tracheal epithelium after mechanical injury I–III. Virchows Arch B 41: 193PubMedGoogle Scholar
  5. 5.
    Keenan KP, Wilson TS, McDowell EM (1983) Regeneration of hamster tracheal epithelium after mechanical injury. Virchows Arch B 43: 213PubMedGoogle Scholar
  6. 6.
    Konrádová V, Šrajer J (1987) Quantitative evaluation of the ciliary border of the epithelium of the rabbit trachea and the human primary bronchus. Folia Morphol 35: 67Google Scholar
  7. 7.
    Konrádová V, Janota J, Šulová J, Suková B, Čopová M (1988) Effects of 90% oxygene exposure on the ultrastructure of the tracheal epithelium in rabbits. Respiration 54: 24.PubMedGoogle Scholar
  8. 8.
    Konrádová V, Kanta J, Šulova J (1990) Effect of bronchoalveolar lavage on the ultrastructure of the tracheal epithelium in rabbits. Respiration (in press)Google Scholar
  9. 9.
    Lundgren R, Horstedt P, Winblad B (1983) Respiratory damage by flexible fibroptic bronchoscopy in pigs. Eur J Resp Dis 64: 24Google Scholar
  10. 10.
    Marin ML, Gordon RE, Lane BP (1979) Development of tight junctions in rat tracheal epithelium during early hours after mechanical injury. Am Rev Resp Dis 119: 101Google Scholar
  11. 11.
    McDowell EM, Ben T, Newkirk C, Chang S, DeLuca LM (1987) Differentiation of tracheal mucociliary epithelium in primary cell culture recapitulates normal fetal development and regeneration following injury in hamsters. Am J Pathol 129: 511PubMedGoogle Scholar
  12. 12.
    Nordin U (1977) The trachea and cuff-induced tracheal injury. Acta Otolarygol (Suppl) 145:1Google Scholar
  13. 13.
    Nordin U (1982) The regeneration after cuff-induced tracheal injury. Acta Otolaryngol 94:541PubMedGoogle Scholar
  14. 14.
    Pavelka M, Ronge HR, Stockinger G (1976) Vergleichende Untersuchungen am Trachealepithel verschiedener Sauger. Acta Anat 94: 262PubMedGoogle Scholar
  15. 15.
    Smith W, Cranken EA (1984) Metrizamide as a contrast medium for visualization of the tracheobronchial tree: its drawbacks and possible advantages: Ped Radiol 14: 158Google Scholar
  16. 16.
    Sturgess JM (1977) The mucous lining of major bronchi in the rabbits lung. Am Rev Resp Dis 115: 819PubMedGoogle Scholar
  17. 17.
    T⫲ma S, Zábrodský V, Brychta O, Povýšilová V, Kanta J, Bŕezovský P, Oštádal B, Kolar F (1990) Hexabrix tracheobronchography in infants. Ped Radiol (in press)Google Scholar
  18. 18.
    Yoneda K (1976) The mucous lining of major bronchi in the rabbit lung. Am Rev Resp Dis 115: 819Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • V. Konrádová
    • 1
  • S. T⫲ma
    • 1
  • J. Kanta
    • 1
  1. 1.Research Institute for Child Development, Faculty of Peiatrics, Pediatric Cardiocentrum and Otorhinolaryngology ClinicUniversity Hospital MotolPrague 5Czechoslovakia

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