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Computer modelling of the binding of non-selective ligands to biological receptors

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Abstract

The application of common linearization methods (logprobit analysis or Hill plot transformation) to the evaluation of receptor binding experiments leads to serious errors, if the ligands used possess insufficient receptor selectivity. The use of simultaneous non-linear curvefitting procedures in this case is recommended and illustrated.

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Authors and Affiliations

  1. Maagdenhuis, University of Amsterdam, Spui 21, 1012, WX Amsterdam, The Netherlands

    H. J. Wynne

  2. Department of Pharmaceutical Chemistry, University of Amsterdam, Plantage Muidergracht 24, 1018, TV Amsterdam, The Netherlands

    D. De Kaste & W. Soudijn

Authors
  1. H. J. Wynne
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  2. D. De Kaste
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  3. W. Soudijn
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Additional information

In honour of Professor Faber on the occasion of his 25-years' professorate.

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Wynne, H.J., De Kaste, D. & Soudijn, W. Computer modelling of the binding of non-selective ligands to biological receptors. Pharmaceutisch Weekblad Scientific Edition 5, 325–328 (1983). https://doi.org/10.1007/BF02074863

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  • DOI: https://doi.org/10.1007/BF02074863

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