Abstract
Objective: Our objective was to assess parameters associated with a successful outcome of intrauterine insemination (IUI) using cryopreserved donor sperm.
Design: We analyzed 750 consecutive donor IUI cycles undertaken by 363 women in an assisted conception clinic. The main outcome measure was clinical pregnancy.
Results: IUI was performed in 94.7% of the 750 IUI treatment cycles commenced and 180 clinical pregnancies occurred. The clinical pregnancy rate per cycle was 26.4%. The rate was significantly related to the patient's age (30.5% for age ≤35 years and 18.1% for age >35 years;P<0.006) and whether there was one or more than one preovulatory follicles [20.9, 34.4, and 31.5% for one, two, and three or four follicles with a mean diameter of 14 or more mm at the time of human chorionic gonadotropin (hCG) administration;P=0.006]. Two to four preovulatory follicles were present in 12.6% of the natural cycles, 43.6% of clomiphene citrate or tamoxifen, and 59.9% of gonadotropin stimulated cycles. The difference in the number of preovulatory follicles between stimulated and unstimulated cycles was highly significant (P<0.0001). Pregnancy rates were 29.9% in gonadotropin-stimulated cycles, 23.6% in clomiphene citrate- or tamoxifen-stimulated cycles, and 20.1% in unstimulated cycles. The difference in pregnancy rates between gonadotropin-stimulated and natural cycles was significant (P=0.038). Cycle fecundity rates were not significantly affected by the number of previous treatment cycles, duration of infertility, gravidity and parity of the patient, presence of a spontaneous luteinizing hormone (LH) surge before the administration of hCG, or number of motile sperm in the insemination specimen.
Conclusions: Success of IUI using cryopreserved donor sperm is related to the age of the women and whether there is one or more than one preovulatory follicles.
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References
Barratt CL, Matson DL, Holt W: British Andrology Society guidelines for the screening of semen donors for donor insemination. Hum Reprod 1993;8:1521–1523
DiMarzo SJ, Huang J, Kennedy JF, Villanueva B, Hebert SA, Young PE: Pregnancy rates with fresh versus computer-controlled cryopreserved semen for artificial insemination by donor in a private practice setting. Am J Obstet Gynecol 1990;162:1483–1488
Chaffkin LM, Nulsen JC, Luciano AA, Metzger DA: A comparative analysis of cycle fecundity rates associated with combined human gonadotropin (hMG) and intrauterine insemination (IUI) versus either hMG or IUI alone. Fertil Steril 1991;55:252–257
Tan SL, Pampiglione J, Steer C, Balen A, Mills C, Campbell S: Transvaginal peritoneal oocyte and sperm transfer for the treatment of nontubal infertility. Fertil Steril 1992;57:850–853
Ord T, Patrizio P, Marello E, Balmaceda JP, Asch RH: Mini-Percoll: A new method of semen preparation for IVF in severe male factor infertility. Hum Reprod 1990;5:987–989
Hurd WW, Randolph JF Jr, Ansbacher R, Menge AC, Ohl DA, Brown AN: Comparison of intracervical, intrauterine, and intratubal techniques for donor insemination. Fertil Steril 1993;59:339–342
Depypere HT, Gordts S, Campo R, Comhaire F: Methods to increase the success rate of artificial insemination with donor semen. Hum Reprod 1994;9:661–663.
Patton PE, Burry KA, Thurmond A, Novy MJ, Wolf DP: Intrauterine insemination outperforms intracervical insemination in a randomized, controlled study with frozen, donor semen. Fertil Steril 1992;57:559–564
Mackenna AI, Zegers-Hochschild F, Fernandez EO, Fabres CV, Huidobro CA, Guadarrama AR: Intrauterine insemination: Critical analysis of a therapeutic procedure. Hum Reprod 1992;7:351–354
Tan SL, Royston P, Campbell S, Jacobs HS, Betts J, Mason B, Edwards RG: Cumulative conception and livebirth rates after in-vitro fertilisation. Lancet 1992;339:1390–1394
Shenfield F, Doyle P, Valentine A, Steele SJ, Tan SL: Effects of age, gravidity and male infertility status on cumulative conception rates following artificial insemination with cryopreserved donor semen: Analysis of 2998 cycles of treatment in one centre over 10 years. Hum Reprod 1993;8:60–64
Federman CA, Dumesic DA, Boone WR, Shapiro SS: Relative efficiency of therapeutic donor insemination using a luteinizing hormone monitor. Fertil Steril 1990;54:489–492
Tan SL, Doyle P, Campbell S, Beral V, Rizk B, Brinsden P, Mason B, Edwards RG: Obstetric outcome of in vitro fertilization pregnancies compared with normally conceived pregnancies. Am J Obstet Gynecol 1992;167:778–784
Uribarren A, Aranguren G, Rodriguez-Escudero FJ, Martinez AJ, Neyro JL: Selective embryo reduction in a sextuplet pregnancy. Fertil Steril 1990;53:1102–1103
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Pittrof, R.U., Shaker, A., Dean, N. et al. Success of intrauterine insemination using cryopreserved donor sperm is related to the age of the woman and the number of preovulatory follicles. J Assist Reprod Genet 13, 310–314 (1996). https://doi.org/10.1007/BF02070144
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DOI: https://doi.org/10.1007/BF02070144