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Progesterone profiles in luteal-phase defects associated with recurrent spontaneous abortions

  • Gynecology
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Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose: Histologically documented luteal-phase defects (LPD) have been detected in 20–40% of women with recurrent spontaneous abortions. In 28 patients with recurrent spontaneous abortions, luteal-phase serum progesterone (P) levels (days 19, 21, 23, 25) and endometrial biopsies were evaluated.

Methods: On the basis of endometrial biopsy findings, the patients were separated into two groups: Group 1, recurrent spontaneous abortions with LPDs (n=18); and Group 2, recurrent spontaneous abortions with normal biopsies (n=7). The data are shown in the table below.

Conclusions: This study demonstrated that the P values found in Group 1 were significantly lower than those in Group 2, almost throughout the luteal phase. The results also indicate a close relationship between the P profile in the luteal phase and endometrial biopsy.

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Authors and Affiliations

  1. Department of Gynaecology and Obstetrics, Vakif Gureba Hospital, Istanbul, Turkey

    Rabiye Babalioğlu & Füsun G. Varol

  2. Department of Pathology, Istanbul Medical School, Istanbul University, Istanbul, Turkey

    Ridvan Ilhan

  3. Department of Gynaecology and Obstetrics, Istanbul Medical School, Istanbul University, Istanbul, Turkey

    Önay Yalçin & Fevzi Çizmecioğlu

Authors
  1. Rabiye Babalioğlu
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  2. Füsun G. Varol
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  3. Ridvan Ilhan
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  4. Önay Yalçin
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  5. Fevzi Çizmecioğlu
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Babalioğlu, R., Varol, F.G., Ilhan, R. et al. Progesterone profiles in luteal-phase defects associated with recurrent spontaneous abortions. J Assist Reprod Genet 13, 306–309 (1996). https://doi.org/10.1007/BF02070143

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  • DOI: https://doi.org/10.1007/BF02070143

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